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The Lumicks C-Trap is a commercial optical tweezer + confocal fluorescence instrument thatcombines powerful technical capabilities with ease-of-use. Measurement of biomolecular forcesand movements at scales relevant to single biomolecules are routine, as well as related assaysin cell mechanics and rheological measurements (e.g. viscosity in phase condensates).
Example Applications
- Measuring force and displacement from protein binding interactions or conformational changes
- Force/displacement in nucleo-protein interactions
- Binding energy measurements
- Cell membrane stiffness measurement
- Phase condensate mechanics, e.g. viscosity or coalescence timescales
Key Features
- Up to four optical traps for flexible experimental geometries
- Sub-pN force resolution
- Sub-nm displacement resolution
- Multicolor confocal imaging
- STED super-resolution imaging
- Optimized workflow allowing even novice users to quickly learn how to collect useful data
