Undergraduate Courses

(3 credits)

This First Year Seminar* surveys the methods of modern medical imaging for clinical and scientific purposes, highlighting basic concepts in chemistry, physics, and biochemistry and especially the biophysical foundations upon which all current tools for biomedical imaging rest. Topics include the underlying science of radiography, computed tomography (X-rays of a selected plane of the body), diagnostic ultrasound, and nuclear medicine. We study magnetic resonance imaging in the context of its historical development and through “reverse engineering” (i.e. understanding how the images are created). This seminar also touches on the societal implications of imaging such as radiation risks, health care costs, and future directions in medical research.

*First Year Seminars are open to Freshmen only.

(3 credits)

This course introduces students to the field of biophysics and its role in the life sciences. The historical example of the discovery of the structure of DNA by Watson and Crick is discussed, and students will have the opportunity to re-create the original experiments that led to the discovery of how DNA governs inheritance. BIOPHYS 120 will be taught in a format that combines lectures, demonstration experiments, and hands-on student experiments.

(3 credits)

This hands-on First Year Seminar* course explores the theory and methods behind synthetic biology, focusing on one particular technology called DNA origami, which uses folded DNA as building blocks to construct nano-scale objects via self-assembly. This class covers the theoretical underpinnings of DNA origami, then students will work in groups to design, construct, and characterize DNA origami objects. Characterization will be accomplished using modern experimental imaging techniques available in the single molecule analysis in real time (SMART) center and/or within research labs on campus. Beyond learning concepts specific to DNA origami, this course aims to expose students to theoretical and experimental methods used in a broad range of biophysics research. The course ends with discussions on how biological materials might impact the future of science and technology at the University of Michigan and beyond.

*First Year Seminars are open to Freshmen only.

(3 credits)

This hands-on interactive course introduces students to the basic programming concepts to assist in reading, processing, producing, and visualizing scientific data. This course gives students the skills needed to independently use computers to conduct basic scientific analysis, and to use and apply resources available online to extend the reach of their coding abilities. While the majority of the course content will be undertaken using Python, a free programming platform that is widely used in the sciences, the emphasis of the class will be on obtaining skills that span programming languages and platforms. The course is structured as a “working laboratory” with students working during class time on instructor-provided coding exercises or student-initiated coding projects. The course uses the GradeCraft course management system and there are no exams. This introductory course is not intended for students who already have extensive programming knowledge.

(4 credits)

Have you ever wondered how physics is important and useful in the fields of biology, chemistry, and medicine? BIOPHYS/PHYSICS 150 is a new introductory physics course that will reveal the synergy between these fields and explore fundamental physics principles that are ubiquitous in the life sciences. Biology, chemistry, and medicine will provide our guiding motivation and context for exploring first-semester physics topics including energy, mechanics, fluids, and thermodynamics. These topics will be covered in the depth and manner in which they appear on the MCAT and in life science courses. In line with this, students will also learn to use quantitative reasoning, develop mathematical models, and engage in scientific dialogue with a diverse group of future scientists and healthcare professionals. This course examines physical concepts through biological examples and consists of both interactive lectures and studio meetings to facilitate student learning and enhance student performance. Lectures will encourage student participation through a variety of in-class activities in which students work directly with, discuss, and respond to lecture material and demonstrations. During studio meetings, students will gain hands-on experience solving problems in small groups, facilitated by an instructor and peer learning assistants.

(3 credits)

This course introduces students to the basic computational and mathematical tools to model biological systems across length scales, from individual molecules to ecosystems, highlighting both the unity and breadth of quantitative approaches aimed at living systems.

(4 credits)

Have you ever wondered how physics is important and useful in the fields of biology chemistry, and medicine? BIOPHYS/PHYSICS 250 is a new introductory physics course that will reveal the synergy between these fields and explore fundamental physics principles that are ubiquitous in the life sciences. Biology, chemistry, and medicine will provide our guiding motivation and context for exploring first-semester physics topics including energy, mechanics, fluids, and thermodynamics. These topics will be covered in the depth and manner in which they appear on the MCAT and in life science courses. In line with this, students will also learn to use quantitative reasoning, develop mathematical models, and engage in scientific dialogue with a diverse group of future scientists and healthcare professionals. This course examines physical concepts through biological examples and consists of both interactive lectures and studio meetings to facilitate student learning and enhance student performance. Lectures will encourage student participation through a variety of in-class activities in which students work directly with, discuss, and respond to lecture material and demonstrations. During studio meetings, students will gain hands-on experience solving physics problems in small groups, facilitated by an instructor and peer learning assistants.

(3 credits)

This course covers how the human body functions and malfunctions from a physics perspective by applying basic physical principles to organs, cells, and biomolecules. It employs extensive A/V and CAI material, and is intended for Biophysics majors and/or students interested in the application of physics to biology, biochemistry, physiology, psychology, genetics, medicine, bioengineering and related life sciences. It provides an introduction to topics in biomechanics, biophysics, and medical physics including biosensors.

(3 credits)

Physical Chemistry is having a major impact on all areas of science that concern the properties of molecules. In particular, the design of pharmaceutical drugs, understanding detailed structure function relationships of proteins, RNA and DNA are highly dependent on the development of physical chemistry concepts.

This course introduces students to physical chemistry (and to the pioneers of these theories) using a biomolecular approach. The underlying principles of quantum mechanics are covered first and then utilized to understand the basic principles of spectroscopy (electronic, vibrational, rotational and magnetic resonance) and other quantum phenomena such as electron/proton tunneling in enzymes. Molecular orbital calculations that can be completed with pencil and paper on simple organic molecules are also covered, giving students a view of theoretical chemistry. 

Armed with the tools of quantum chemistry, students shall learn that the laws of thermodynamics can be formulated in terms of the properties of atoms and molecules that make up macroscopic systems. Students will then utilize these concepts to understand the workings of (bio)molecular machines. Mathematical topics are reviewed before using them to develop biophysical chemistry concepts.

The outcome of this course will provide students with the ability to understand research problems in biotechnology and medical fields from a physical chemistry perspective.

(1-4 credits)

Research in a modern research laboratory, under the direction and supervision of a faculty member, is a required part of the Biophysics curriculum to prepare students adequately for their future careers as a biophysicist in academic or industrial research.

This course number is used for an individualized research experience under the guidance of a Biophysics faculty member.  If a non-Biophysics faculty member serves as the principal mentor, a Biophysics faculty member must be identified as a co-mentor. Students need permission from their biophysics faculty mentor before they can enroll in this course. Typically, students will work on a small, well-defined project that may subsequently turn into a senior or honor's thesis. 

The student is expected to work on a research project under the direct supervision of the faculty mentor, who accepts responsibility for all aspects of the student's work. Each credit hour is equivalent to at least four hours a week of actual work in the lab for a 14 week term (minimum 50 hours per term-credit hour). The faculty mentor may delegate some day-to-day supervisory functions to a post-doc or graduate student, but the mentor is nonetheless expected to meet regularly with the student and monitor his or her progress. The mentor is also responsible for assigning a grade at the end of the semester. In case of co-mentorship for a project under the guidance of a non-Biophysics faculty member, the Biophysics co-mentor is expected to take responsibility for the overall appropriateness of the project, ensure that the principal mentor fulfills his or her mentoring obligations towards the student, and, in consultation with the principal mentor, assign a grade.

Students are required to submit a one-page report on his or her research project at the end of the semester.  Reports are submitted both to the faculty mentor and to the Biophysics main office for student records.

(1-3 credits)

This course will cover different topics of special interest within Biophysics.

(1-4 credits)

This course number is used for individualized instruction in biophysics in lieu of a regular classroom course. The primary purpose is to allow instructors to teach courses on subjects that are not in the course catalog in a one-on-one format. In exceptional cases, such as when the program is unable to offer a particular course in a timely manner for a student to graduate, courses that are already in the course catalog for regular classroom instruction may be offered in this format as well. In any case, the instructor is expected to meet regularly with the student in person; this responsibility cannot be delegated.
Before a student can enroll in this course, the faculty member who wishes to teach it must submit a syllabus that includes the required work and the grading standards to the Associate Chair for the Undergraduate Program for approval. At the end of the semester, the instructor assigns a grade for the course and submits copies of the student’s work on which the grade is based to the Biophysics business office for the records of the program.

(3 credits)

The physical basis of diffusive processes in biology and biochemistry, and optical spectroscopic means for measuring its rates. Topics include: membrane electrical potentials, nerve impulses, synaptic transmission, the physics of chemoreception by cells, motion and reaction kinetics of membrane components, optical microscopy, visible and UV light absorption, fluorescence and phosphorescence, quasielastic light scattering, mathematics of random fluctuations, and chaotic processes in biology.

(3 credits)

Properly folded biological macromolecules help us think, feel and do. When things go wrong they cause disease. What is the physical basis for strings of amino acids (or, sometimes, nucleobases) assembling into well-folded structures in order to perform the tasks essential for life?

This course focuses on an in-depth treatment of topics including secondary and tertiary structures of biological macromolecules including proteins, DNA and RNA, folding and misfolding of proteins, ensemble and single-molecule kinetics, protein-protein interactions and biochemistry of cellular processes.

(3 credits)

This course builds on the Biophysics 420 sequence and aims at providing a complete understanding of the roles of structure and dynamics on the function of biological macromolecules such as globular proteins, membrane proteins, DNA and RNA. This course also focuses on the analysis and interpretation of various biophysical experimental and computational data for biological macromolecules including x-ray diffraction, microscopic and fluorescence images, multidimensional NMR spectra, EPR spectra, ion-channel recordings and single molecular experimental data. Students will be trained with the steps involved in handling the experimental data to solve and understand the structures of biomolecules. 

(3 credits)

This course offers a detailed introduction to the fundamental physical principles behind key structural techniques including X-ray crystallography, NMR spectroscopy and cryo-electron microscopy. Students will gain hands-on experience with data processing, analysis and structure calculations/model building.

(3 credits)

This course introduces biomedical imaging techniques and medical physics based therapies, elucidates the physical principles behind them, and discusses the interaction of different kinds of radiation with biological matter. Examples for covered imaging techniques are ultrasound, X-ray imaging, CAT scan, MRI imaging, and positron emission tomography. Relevant radiotherapy methods include the gamma knife, brachytherapy, and proton-beam therapy.

(3 credits)

This course explores concepts of nonlinear dynamics in biological systems. It covers fixed points, logistic maps, chaotic oscillators, waves in excitable media and spatio-temporal pattern formation in biological systems ranging from cells to organs such as the brain and populations.

(3 credits)

This course introduces students to the basic concepts of biophysical modeling. Methods such as molecular dynamics and Brownian Dynamics simulations, as well as larger-scale models for regulatory networks are covered and the associated computational tools are introduced.

(3 credits)

This course deconstructs current and emerging diseases in terms of the malfunctioning of nucleic acids, proteins, and membranes and interactions between them. The diseases covered will include Alzheimer’s, Parkinson’s, Creutzfeldt-Jakob disease (or Mad-Cow disease), HIV, a variety of bacterial infections, and other biological disorders. A variety of biophysical methods for dissecting diseases at the atomic level will be surveyed, including NMR spectroscopy, X-ray crystallography, cryo-electron microscopy, single molecule imaging, and computational methods.

The course will emphasize how a basic biophysical understanding of diseases can guide the rational design of therapeutics, to include:

• Infectious diseases
• The Molecules of Life: Biophysical Principles
• Viral Infections
• Bacterial Infections
• Health Conditions
• Rational Approaches to Drug Discovery

(3 credits)

This course introduces the basic tools of Information Theory -- Entropy, Relative Entropy and Information - and highlights their utility with applications drawn from various disciplines. After introducing the basics of probability theory and information theory, other topics like coding, data compression, channel capacity, thermodynamics, population dynamics, gene transcriptions, network science are explored.

(3 credits)

This hands-on course teaches essential laboratory skills in Biophysics. Experiments cover sample preparation techniques, such as protein expression and purification; modern research methods such as atomic force microscopy, optical tweezers, NMR, X-ray crystallography, and computational techniques such as molecular dynamics simulation. The final project will allow students to explore a topic of interest in greater depth.

(3 credits)

This course builds on the CHEM 451-453 sequence and aims at providing an understanding of the structure and dynamics of biological macromolecules. After introducing the necessary nomenclature and reviewing thermodynamic principles, modern techniques to characterize the structure and dynamics of biopolymers is the focus. Sedimentation, electrophoresis, mass spectrometry, X-ray diffraction, scattering, and spectroscopic techniques such as absorption, circular dichroism, fluorescence, and NMR are covered. Both physical principles and practical applications in the Life Sciences are highlighted.

(3 credits)

The complexity of the biological sciences makes interdisciplinary involvement essential and the increasing use of mathematics in biology is inevitable as biology becomes more quantitative. Mathematical biology is a fast growing and exciting modern application of mathematics which has gained worldwide recognition. In this course, mathematical models that suggest possible mechanisms which may underlie specific biological processes are developed and analyzed. Another major emphasis of the course is illustrating how these models can be used to predict what may follow under currently untested conditions. The course moves from classical to contemporary models at the population, organ, cellular, and molecular levels.

(3 credits)

This course teaches professional skills such as writing research articles, reviews, grant proposals, and preparing and giving poster presentations and scientific talks. The scientific publishing process, including peer review, will be discussed and ethical rules and considerations explored. All students will draft an application for an NSF Graduate Fellowship, which will be extensively critiqued by other students and the instructor.

(1-4 credits)

This course gives Biophysics majors (at the senior level) the opportunity to cap their educational experience with a senior thesis based on their research. It will typically be a continuation of Biophysics 399.

(1-4 credits)

This course gives Biophysics Honors concentrators (at the senior level) the opportunity to cap their educational experience with an honors thesis based on their research. It is typically a continuation of Biophysics 399.