Biophysics Seminar: "The Versatile Beta-Barrel Gives Up Secrets of the Membrane"

Abstract:

The protein-folding problem is one of the contemporary challenges of biophysics. Knowing how the sequence encodes a native structure will provide insight into how genetic mutations cause disease, how protein sequences evolve and represents a tool to design proteins with novel structures and functions. While the folding of soluble proteins has been studied for decades, studies on membrane proteins are not as common. In this talk, I will present our recent developments in membrane protein stability measurements in vitro as well as their implications in living cells.