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Membrane Biophysics

It is estimated that one-third of all eukaryotic proteins are membrane bound. Membrane proteins act as enzymes, regulate transport processes, and play a central role in intercellular communication. At Michigan, structure determinations of membrane proteins, which are difficult to crystallize, are made possible by recent advances in solid-state NMR spectroscopy. Other research focuses on topics ranging from posttranslational modifications of membrane-bound central nervous system proteins to the population response of neurons to outside stimuli in live animals.