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Michigan has one of the largest groups of researchers actively working on all aspects of enzyme structure and mechanism. Biophysics faculty integrate many of the techniques described above in the study of a wide variety of protein and RNA enzyme reactions, often in the context of understanding diseases or for environmental applications.

Catalysis by the hairpin ribozyme (stick figure) is monitored in real-time by single molecule FRER microscopy (background); the enzyme isaccelerated by tertiary structure formation (3-D plot). Rueda, D., Bokinsky, g., Rhodes M.M., M.J., Zhuang X., and Walter, N.G. (2004) Proc. Natl. Acad. Sci. USA 101 p. 10066-10071