To support the computational discovery required for this grant, we will use computing cycles on Flux, a commodity HPC cluster based on the Intel Nehalem platform interconnected with Infiniband networking. Each compute node comprises two 6-core CPUsand 48 GB of RAM (approximately 4GB of RAM per CPU core). The Infiniband interconnect provides 40 GB/s bandwidth and very low latency. If technology advances between thetime of this proposal and the start period of the grant, the system may be upgraded as Flux hardware and software is refreshed regularly to stay current with evolving technology. The Flux cluster includes a comprehensive software suite of commercial and open source research software, including major software compilers, and many of the common research specific applications such as Mathematica, matlab, R and stata. Funds needed for group-specific software will be acquired by individual Project investigators through research grants. The system also includes a 150 terabyte scratch storage using the Lustre parallel network filesystem. This filesystem is for the explicit purpose to allow researchers to store data on a short term basis to solely to perform calculations, and not for any longterm data storage or archive purposes. The cluster and storage is located in a machine room at the University of Michigan. The machine room is a 10,000ft square foot facility with air conditioning and a conditioned, uninterruptible, and generator-backed power supply with sufficient space, power, and cooling capacity to support the proposed hardware as well as any future expansions of this system.This system is connected to the campus backbone to provide access fromstudent and researcher desktops.