Ryan Bailey

Biology is continuously advanced by improvements in measurement technologies, experiencing paradigm shifts due to the deeper levels to which scientists can peer into a system. Armed with the fruits of the genomic and proteomic revolutions, biomedicine is now primed for technologies that integrate multiparameter gene and protein profiling and are applicable within the clinical setting. By combining traditional chemical and biological insight with cutting-edge concepts from materials science, physics, and engineering, our group brings an interdisciplinary approach to developing new tools to tackle longstanding, refractory problems in the biomolecular sciences—technologies that will enable fundamental biological discovery, and in some applications, expedite the transfer of biomolecular insight to the hands of the physician where it can directly impact patient care.

Motivated by practical challenges associated with performing multiparameter biological analysis, our group is developing several powerful analysis tools that will be applicable in clinical settings and beyond. Our goal is to facilitate personalized diagnosis and individualized treatment by providing a more detailed picture of the biomolecular signatures of disease from a single patient. On account of their simplicity, scalability, and molecular generality, these tools also have broad applicability to many aspects of clinical and pharmaceutical research as well as fundamental biological studies.

Publications

Multiplexed Cancer Biomarker Detection Using Chip-Integrated Silicon Photonic Sensor Arrays, A.L. Washburn, W.W. Shia, K.A. Lenkeit, S.-H. Lee, R.C. Bailey Analyst, 2016, Advance Article
DOI: 10.1039/C6AN01076H

Nanoporous Gold Membranes as Robust Constructs for Selectively Tunable Chemical Transport, D.A. McCurry, R.C. Bailey, Journal of Physical Chemistry C, 2016, ASAP
DOI: 10.1021/acs.jpcc.6b02759

Applications of Optical Microcavity Resonators in Analytical Chemistry, J.H. Wade, R.C. Bailey, Annual Reviews in Analytical Chemistry, 2016, 9, 1-25.

Increasing the strength and bioactivity of collagen scaffolds using customizable arrays of 3D-printed polymer fibers, L.C. Mozden, R. Rogers, J.M. Banks, R.C. Bailey, B.A. Harley, Acta Biomaterialia, 2016, 33, 25-33.

Emerging Biosensing Approaches for microRNA Analysis, R.M. Graybill, R.C. Bailey, Analytical Chemistry, 2016, 88, 431-450.

Development and validation of an immunosensor for monocyte chemotactic protein 1 using a silicon photonic microring resonator biosensing platform, E. Valera, W.W. Shia, R.C. Bailey, Clinical Biochemistry, 2016, 49, 121-126.

Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays, J.H. Wade, A.T. Alsop, N.R. Vertin, H. Yang, M.D. Johnson, R.C. Bailey, ACS Central Science, 2015, 1(7), 374-382.

Bioanalytical chemistry: Eavesdropping on interactions, E. Valera, R.C. Bailey, Nature Chemistry, 2015, 7, 767-779.

A tunable, photoreactive hydrogel system to probe synergies between mechanical and biomolecular cues on adipose-derived mesenchymal stem cell differentiation, J.M. Banks, B.A. Harley, R.C. Bailey, ACS Biomaterials Science & Engineering, 2015, 1(8), 718-725. 

Magnetically-actuated, bead-enhanced silicon photonic immunosensor, E. Valera, M. S. McClellan, R.C. Bailey, Analytical Methods, 2015, 7, 8539-8544.

Research Areas(s)

• Analytical Chemistry
  Bioanalytical Chemistry
  Biophysical Chemistry
  Chemical Biology
  Materials Chemistry
  Optics & Imaging
  Sensor Science
  Nanoscale Analytics
  Chemical Separations
  Microfluidics
  Physical Chemistry