Professor of Psychiatry; Research Associate Professor, Molecular& Behavioral Neuroscience Institute;
Adjunct Professor of Psychology
There is tremendous interest in finding interactions between biological factors and stress in the development of depression. Progress has been limited however, because it is difficult to predict the onset of stress beforehand and because the type of stress encountered varies widely between individuals. In our primary study, we seek to overcome these barriers by utilizing medical internship as a model of stress. Medical internship, the first year of professional physician training, presents a unique situation where the onset of a uniform, substantial stressor can be prospectively predicted. To identify genes involved in depression, we are performing genome-wide association and coding exome studies on a sample of over 10,000 interns. Beyond genes, we are utilizing the internship model to identify, psychological factors, epigenetic patterns and serum protein levels that moderate the relationship between stress and depression.
1) RELEVANT PUBLICATIONS
D Mata, M Ramos, MM Kim, C Guille and S Sen. 2016. In Their Words: An Analysis of the Experiences of Medical Interns Reported During a Prospective Cohort Study of Depression. Academic Medicine (in press)
D Mata, M Ramos, N Bansal, R Khan, C Guille, E Di Angelantonio and S Sen. 2015. Prevalence of Depression and Depressive Symptoms among Resident Physicians. JAMA. 314 (22), 2373-2383.
C Guille, J Krystal, B Nichols, J Zhao, K Brady and S Sen. 2015. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Controlled Trial. JAMA Psychiatry. 72(12), 1192-1198
J Fiedorowicz, V Ellingrod, M Kaplan and S Sen. 2015. The Development of Depressive Symptoms During Medical Internship Stress Predicts Worsening Vascular Function. Journal of Psychosomatic Research. Sep;79(3):243-5.
E Fried, R Nesse, K Zivin, C Guille and S Sen. 2013. Depression is More than the Sum of Its Parts: Individual DSM Symptoms Have Different Risk Factors. Psychological Medicine. Dec 2:1-10
S Sen, HK Kranzler, AK Didwania, AC Schwartz, S Amarnath, JC Kolars, GW Dalack, B Nichols and C Guille. 2013. Effects of the 2011 Duty Hour Reforms on Interns and Their Patients: A Prospective Longitudinal Cohort Study. JAMA Internal Medicine. 173(8):657-62.
C Guille and S Sen. 2012. Prescription Drug Use and Self-prescription Among Training Physicians. Archives of Internal Medicine. 172(4):371-372.
K Karg, K Shedden, M Burmeister and S Sen. 2011. The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-Analysis Revisited: Evidence of Genetic Moderation. Archives of General Psychiatry May;68(5):444-54.2)
2) RELATED NEWS
TIME Magazine August 28, 2015 LIFE / SUPPORT Doctors are stressed, burned out, depressed ...... save the mental health of America's doctors.
Harper's Index http://harpers.org/archive/2015/11/harpers-index-377/ November, 2015Portions of physicians who suffer from depression at their internship: 1/2
The Michigan Daily Web therapy helps first-year medical students fight depression. https://www.michigandaily.com/section/news/new-app-can-prevent-suicidal-thoughts-first-year-medical-residents By Sanjay Reddy / November 24, 2015
The New York Times. Drugs, Talk Therapy and the Brain. http://www.nytimes.com/2015/07/22/opinion/drugs-talk-therapy-and-the-brain.html July, 2015
The New York Times Silence Is the Enemy for Doctors Who Have Depression http://www.nytimes.com/2016/01/12/upshot/silence-is-the-enemy-for-doctors-who-have-depression.html?_r=1 By Aaron E. Carroll / Jan. 11, 2016