For decades, Big Food has been marketing products to people who can’t stop eating, and now, suddenly, they can. The active ingredient in Ozempic, as in Wegovy, Zepbound and several other similar new drugs, mimics a natural hormone, called glucagon-like peptide-1 (GLP-1), that slows digestion and signals fullness to the brain. Around seven million Americans now take a GLP-1 drug, and Morgan Stanley estimates that by 2035 the number of U.S. users could expand to 24 million. That’s more than double the number of vegetarians and vegans in America, with ample room to balloon from there. More than 100 million American adults are obese, and the drugs may eventually be rolled out to people without diabetes or obesity, as they seem to tame addictions beyond food — appearing to make cocaine, alcohol and cigarettes more resistible. Research is at an early stage, but they may also cut the risk of everything from stroke and heart and kidney disease to Alzheimer’s and Parkinson’s.

The prospect of tens of millions of people cutting their caloric intake down to roughly 1,000 per day, which is half the minimum amount recommended for men, is unsettling the industry. Late last year, Lars Fruergaard Jorgensen, the chief executive of Novo Nordisk, which makes Ozempic and Wegovy, told Bloomberg that food-industry executives had been calling him. “They are scared about it,” he said. Around the same time, Walmart’s chief executive in the United States, John Furner, said that customers on GLP-1s were putting less food into their carts. Sales are down in sweet baked goods and snacks, and the industry is weathering a downturn. By one market-research firm’s estimate, food-and-drink innovation in 2024 reached an all-time nadir, with fewer new products coming to market than ever before.

Ozempic users like Taylor aren’t just eating less. They’re eating differently. GLP-1 drugs seem not only to shrink appetite but to rewrite people’s desires. They attack what Amy Bentley, a food historian and professor at New York University, calls the industrial palate: the set of preferences created by our acclimatization, often starting with baby food, to the tastes and textures of artificial flavors and preservatives. Patients on GLP-1 drugs have reported losing interest in ultraprocessed foods, products that are made with ingredients you wouldn’t find in an ordinary kitchen: colorings, bleaching agents, artificial sweeteners and modified starches. Some users realize that many packaged snacks they once loved now taste repugnant. “Wegovy destroyed my taste buds,” a Redditor wrote on a support group, adding: “And I love it.”

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