About
I am a neurobiologist and cancer immunologist in the MCDB Department, where teaching is my primary focus. In parallel, I maintain active research involvement as a co-Principal Investigator in Duan-Lab. My work focuses on neuro-immune interactions and the molecular mechanisms of cell death, and I am committed to mentoring students in both research and scholarly development.
Selected Publications:
Hu M, Li P, Wang C, Feng X, Geng Q, Chen W, Marthi M, Zhang W, Gao C, Reid W, Swanson J, Du W, Hume RI, Xu H. Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. Cell. 2022 Jun 23;185(13):2292-2308.
Gu M, Hu M, Minckley T, Pinchi P, Xu H, Qin Y, Du W#. A protocol to measure lysosomal Zn2+ release through a genetically encoded Zn2+ indicator. STAR Protoc. 2022 Jun 10;3(2):101453.
Du W#, Gu M, Hu M, Pinchi P, Chen W, Ryan M, Nold T, Bannaga A, Xu H. Lysosomal Zn2+ release triggers mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 2021 Oct 19;37(3):109848.
Du W, Seah I, Bougazzoul O, Choi G, Meeth K, Bosenberg MW, Wakimoto H, Fisher D, Shah K. Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6157-E6165.
Du W, Huang J, Yao H, Zhou K, Duan B, Wang Y. Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats. J Clin Invest. 2010 Oct;120(10):3480-92.
Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, Wang Y. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci. 2008 Jul 15;121(Pt 14):2301-7.
Zhou J*, Du W*, Zhou K, Tai Y, Yao H, Jia Y, Ding Y, Wang Y. Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci. 2008 Jul;11(7):741-3.
* Co-equal contribution; # Corresponding author.
A full list of publications is in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/
