Kwoon Wong

Vision is our most important sense, enabling us to discern the identity and movement of objects in our surroundings. In addition to such “image-forming” functions, our visual system supports a variety of “non-image-forming” responses to environmental light. Examples of these largely subconscious visual responses include constriction of the pupil, synchronization of daily physiological rhythms to the light/dark cycle (i.e. circadian photoentrainment), acute enhancement of alertness, regulation of hormone secretion, and rudimentary light recognition in some blind patients.

Both types of visual processing begin in the retina. One of the most surprising recent discoveries in neuroscience is that, unlike image-forming vision, non-image-forming vision does not require rod or cone photoreceptors. This is because non-image-forming photoreception is mediated not only by rods and cones, but also by intrinsically photosensitive retinal ganglion cells (ipRGCs), a rare type of ganglion cell that expresses the light-sensing molecule melanopsin and functions as a photoreceptor. Dr. Wong’s laboratory is using electrophysiology, immunohistochemistry, and behavioral assays to answer the following questions:

1. How do ipRGCs respond to different kinds of light? What stimuli optimally activate ipRGCs and non-image-forming visual responses?
2. How do ipRGCs interact with other neurons in the retina?
3. Six types of ipRGCs have been discovered in mice. What are their functional roles?

The long-term goal of Dr. Wong’s research is to generate data that may guide the invention of: 

1. Drugs and light therapies for treating jet lag, sleep disorders, and depression
2. Daytime lighting technologies that maximize alertness and hence productivity at work and school
3. Nighttime lights that minimize the harmful effects of nocturnal light exposure while supporting image-forming visual tasks such as reading
4. Pharmacologic agents and electronic devices that enhance the visual capabilities of people who are blind

Dr. Wong is also collaborating with four labs in the Department of Ophthalmology & Visual Sciences to investigate:

1. An innovative strategy for retinal prosthesis

2. Using photoacoustic imaging to quantify visual-evoked hemodynamic responses in mouse brain

3. Using glia-derived neurons to treat retinal degeneration

4. Visual signaling in mouse models of demyelination