Professor, Director, Undergraduate Program in Neuroscience
About
Current research in the Duan lab focuses on studying developmental and cell plasticity. Using zebrafish and cultured human cells, the Duan lab has discovered several conserved mechanisms regulating developmental and cell plasticity. Many are converged onto the insulin/insulin-like growth factor (IIS)-PI3 kinase-Akt-Tor signaling pathway. The Duan lab is also contributing to our understanding of hypoxia and HIF biology.
Dr. Duan received his doctoral degree from University of Tokyo and was a postdoctoral fellow at University of Washington and University of North Carolina at Chapel Hill.
Recent Publications:
Li, Y., Liu, C., Rolling, L., Sikora, V., Chen, Z., Gurvin, J., Barabell, C., Lin, J., and Duan, C. (2023) ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. PNAS, 120: e2216310120.
Li, S., Liu, C., Goldstein, A., Xin, Y., Ke, C., and Duan, C. (2021) Calcium state-dependent regulation of epithelial cell quiescence by Stanniocalcin 1a. Front. Cell Dev. Biol. 9: 662915. doi: 10.3389/fcell.2021.662915.
Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A. K., Goldstein, A., Ke, C., Oxvig, C., and Duan, C. (2020) The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. eLife 2020;9:e52322.
Xin, Y., Malick, A., Hu, M., Liu, C., Batah, H., Xu, H., and Duan, C. (2019) Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. eLife 8:e48003.
Liu, C.*, Xin, Y.*, Bai, Y., Lewin, G., He, G., Mai, K., and Duan, C. (2018) Ca2+ concentration-dependent premature death of igfbp5a-/- fish reveals a critical role of IGF signaling in adaptive epithelial growth. Science Signaling, 11, eaat2231.
Field(s) of Study
- Molecular and Developmental Endocrinology
Areas of Focus
- Cell Biology
- Development
- Neurobiology & Animal Physiology
