About
The Duan Lab has a long-standing interest in understanding the regulation, function, and evolution of the nutrient-sensitive insulin and insulin-like growth factor (IIS) hormonal pathways. Our research focuses on the role of the IIS signaling in regulating cell plasticity in response to hypoxia, nutrient deficiency, and acidosis. Our recent work has expanded into regulation of calcium metabolism, bone mineralization, and renal mineral balance. The Duan lab has also been contributing to advancing the understanding of hypoxia and HIF biology.
Dr. Duan received his doctoral degree from University of Tokyo and was a postdoctoral fellow at University of Washington and University of North Carolina at Chapel Hill.
Recent Publications:
Duan, C. (2026) Stannioaclcin 1 at the nexus of calcium homeostasis, IGF signaling, and tumor immunity. Endocrine Reviews, DOI: 10.1210/endrev/bnag026
Choi, E.#, Duan, C.#, and Bai. X.# (2025) Regulation and function of insulin and insulin-like growth factor receptor signaling. Nat. Rev. Mol. Cell Biol. https://www.nature.com/articles/s41580-025-00826-3; # Corresponding author.
Li, Y., Liu, C., Rolling, L., Sikora, V., Chen, Z., Gurvin, J., Barabell, C., Lin, J., and Duan, C.# (2023) ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Proc. Natl. Acad. Sci. USA, 120(24):e2216310120. e2216310120.
Field(s) of Study
- Molecular and Developmental Endocrinology
Areas of Focus
- Cell Biology
- Development
- Neurobiology & Animal Physiology
