Research in our lab is directed towards understanding cellular response to stress. We use the yeast Saccharomyces cerevisiae which allows for a combined genetic and biochemical approach. Currently, we are pursuing several areas of interest, focusing on organellar functions and interactions. Recently we discovered that in adaptive response to stress associated with protein misfolding in the endoplasmic reticulum, the mitochondria undergo a remodeling process. Ongoing work is focused on understanding the signaling events to initiate mitochondrial remodeling and modulate mitochondrial activity, and the critical transcriptional, translational and protein assembly events necessary to remodel mitochondrial components. The cellular processes we study are important to understanding human health, as a wide range of diseases are associated with endoplasmic reticulum stress, and mitochondrial dysfunction.
Dr. Chang received her A.B. from Harvard University, her Ph.D. degree from Yale University, and she did postdoctoral training at Yale University and the Whitehead Institute at MIT.
Field(s) of Study:
- Cell and Molecular Biology
Areas of Focus:
- Cell Biology