Friday, March 5, 2021
12:00-1:00 PM
Virtual
The Biophysics Virtual Seminar Series presents:
Dr. Samuel Butcher - Steenbock Professor of Biomolecular Structure, Department of Biochemistry, University of Wisconsin-Madison
“The epitranscriptome has been shaped by the co-evolution of RNA writer and reader proteins.”
ABSTRACT: The epitranscriptome is characterized by dozens of post-transcriptional chemical modifications to RNA. These chemical modifications are catalyzed by enzymes, or “writers” that chemically mark both coding and non-coding RNAs. The post-transcriptional marks are then read by protein “readers” that bind to the RNA modifications and help direct their cognate RNAs towards different pathways in the cell. I will present our work showing how RNA writers
and readers have co-evolved to shape the epitranscriptome input and output. A series of comparative molecular structures will be described that illustrate how very subtle changes in enzyme active sites of RNA modifying enzymes result in different chemical marks that have co-
evolved with RNA reader proteins, which can adopt modular quaternary structures that are specifically tuned to read different modifications. This co-evolution of RNA writers and readers impacts nearly every step of eukaryotic gene expression.
Join us on Zoom: https://umich.zoom.us/j/92759610297
Dr. Samuel Butcher - Steenbock Professor of Biomolecular Structure, Department of Biochemistry, University of Wisconsin-Madison
“The epitranscriptome has been shaped by the co-evolution of RNA writer and reader proteins.”
ABSTRACT: The epitranscriptome is characterized by dozens of post-transcriptional chemical modifications to RNA. These chemical modifications are catalyzed by enzymes, or “writers” that chemically mark both coding and non-coding RNAs. The post-transcriptional marks are then read by protein “readers” that bind to the RNA modifications and help direct their cognate RNAs towards different pathways in the cell. I will present our work showing how RNA writers
and readers have co-evolved to shape the epitranscriptome input and output. A series of comparative molecular structures will be described that illustrate how very subtle changes in enzyme active sites of RNA modifying enzymes result in different chemical marks that have co-
evolved with RNA reader proteins, which can adopt modular quaternary structures that are specifically tuned to read different modifications. This co-evolution of RNA writers and readers impacts nearly every step of eukaryotic gene expression.
Join us on Zoom: https://umich.zoom.us/j/92759610297
| Building: | Off Campus Location |
|---|---|
| Location: | Virtual |
| Event Link: | |
| Website: | |
| Event Type: | Livestream / Virtual |
| Tags: | Chemistry, Complex Systems, Physics, seminar |
| Source: | Happening @ Michigan from LSA Biophysics |
