Friday, October 23, 2020
12:00-1:00 PM
Virtual
Please see below for the link to join the Zoom event.
The Biophysics Virtual Seminar Series presents:
Dr. Sandra Schmid - Chief Scientific Officer, Chan Zuckerberg Biohub
“Dynamin: A catalyst for fission, collaboration and controversy”
ABSTRACT: Kazuo Ikeda’s beautiful electron micrographs of neuromuscular junctions of Drosophila shibire mutants revealed the presence of collar-like structures around the necks of trapped endocytic intermediates. They inspired my 30 year-long obsession with dynamin, the mammalian homologue of shibire. Our subsequent studies of dynamin, which began in the early 90s provide benefitted from the development of new technologies and from interdisciplinary collaboration. I’ll describe the twists and turns of our efforts to understand the mechanisms underlying dynamin-catalyzed fission, the value of interdisciplinary collaborations, and the importance of taking all data into account when formulating models. I’ll detail our current understanding of dynamin-catalyzed fission, now supported by independent studies of others, and briefly describe the many remaining unanswered questions, keeping in mind (in the words of George Box) that, “All models are wrong, but some are useful."
The Biophysics Virtual Seminar Series presents:
Dr. Sandra Schmid - Chief Scientific Officer, Chan Zuckerberg Biohub
“Dynamin: A catalyst for fission, collaboration and controversy”
ABSTRACT: Kazuo Ikeda’s beautiful electron micrographs of neuromuscular junctions of Drosophila shibire mutants revealed the presence of collar-like structures around the necks of trapped endocytic intermediates. They inspired my 30 year-long obsession with dynamin, the mammalian homologue of shibire. Our subsequent studies of dynamin, which began in the early 90s provide benefitted from the development of new technologies and from interdisciplinary collaboration. I’ll describe the twists and turns of our efforts to understand the mechanisms underlying dynamin-catalyzed fission, the value of interdisciplinary collaborations, and the importance of taking all data into account when formulating models. I’ll detail our current understanding of dynamin-catalyzed fission, now supported by independent studies of others, and briefly describe the many remaining unanswered questions, keeping in mind (in the words of George Box) that, “All models are wrong, but some are useful."
| Building: | Off Campus Location |
|---|---|
| Location: | Virtual |
| Event Link: | |
| Website: | |
| Event Type: | Livestream / Virtual |
| Tags: | Biophysics, Free, Industry Session, Research, seminar, Virtual |
| Source: | Happening @ Michigan from LSA Biophysics |
